Rabbit Secondary Antibodies
ABclonal Technology PE Rabbit anti-Human CD4 mAb
This gene encodes the CD4 membrane glycoprotein of T lymphocytes The CD4 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class II MHC molecules The CD4 antigen is also a primary receptor for entry of the human immunodeficiency virus through interactions with the HIV Env gp120 subunit This gene is expressed not only in T lymphocytes but also in B cells macrophages granulocytes as well as in various regions of the brain The protein functions to initiate or augment the early phase of T-cell activation and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene
ABclonal Technology 594 Rabbit anti-Human DLL4
This gene is a homolog of the Drosophila delta gene The delta gene family encodes Notch ligands that are characterized by a DSL domain EGF repeats and a transmembrane domain
ABclonal Technology 594 Rabbit anti-Human CD172b
The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family and also belongs to the immunoglobulin superfamily SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes This protein was found to interact with TYROBP DAP12 a protein bearing immunoreceptor tyrosine-based activation motifs This protein was also reported to participate in the recruitment of tyrosine kinase SYK Multiple transcript variants encoding different isoforms have been found for this gene
ABclonal Technology 488 Rabbit anti-/Human CD55
This gene encodes an inhibitor of both the classical and the alternative pathways of complement activation The encoded preproprotein undergoes post-translational processing to generate a mature polypeptide anchored to the plasma membrane via a glycosylphosphatidylinositol moiety Erythrocytes from mice deficient in the encoded protein exhibit impaired regulation of complement activation resulting in enhanced complement deposition Mice lacking the encoded protein exhibit enhanced susceptibility to experimentally induced myasthenia gravis This gene is located adjacent to a closely related gene on chromosome 1
Biotang Inc Anthrax PA Polyclonal Antibody, Anthrax PA Antibody, Rabbit Anti Human Polyclonal Antibody.
Anthrax PA Polyclonal Antibody, Anthrax PA Antibody, Rabbit Anti Human Polyclonal Antibody.
ABclonal Technology 700 Rabbit anti-Human EGFR
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily This protein is a receptor for members of the epidermal growth factor family EGFR is a cell surface protein that binds to epidermal growth factor thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation Mutations in this gene are associated with lung cancer EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)
ABclonal Technology 450 Rabbit anti-Human CD97
This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors which mediate cell-cell interactions These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit which associate at the cell surface as a receptor complex The encoded protein may play a role in cell adhesion as well as leukocyte recruitment activation and migration and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55 Expression of this gene may play a role in the progression of several types of cancer Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19
ABclonal Technology 450 Rabbit anti-Human CD138
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family The syndecans mediate cell binding cell signaling and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins Altered syndecan-1 expression has been detected in several different tumor types While several transcript variants may exist for this gene the full-length natures of only two have been described to date These two represent the major variants of this gene and encode the same protein
ABclonal Technology 647 Rabbit anti-Human CD30
The protein encoded by this gene is a member of the TNF-receptor superfamily This receptor is expressed by activated but not by resting T and B cells TRAF2 and TRAF5 can interact with this receptor and mediate the signal transduction that leads to the activation of NF-kappaB This receptor is a positive regulator of apoptosis and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported
ABclonal Technology 594 Rabbit anti-Human CD146
Melanoma cell adhesion molecule (MCAM MUC18 CD146) is an immunoglobulin superfamily member identified as a cell surface adhesion protein and a marker for melanoma progression and metastasis MCAM is expressed in vascular endothelial cells activated T lymphocytes smooth muscle and bone marrow stromal cells Its expression increases in endothelial cells from angiogenesis-related disorders such as inflammatory bowel disease Crohn s disease rheumatoid arthritis tumors and chronic renal failure MCAM-expressing human mesenchymal stromal cells (hMSC) help maintain the self-renewal of hematopoietic stem and progenitor cells (HSPC) through direct contact possibly involving Notch signaling Research suggests MCAM also plays a role in multiple sclerosis where endothelial MCAM in the blood-brain barrier facilitates lymphocyte transmigration contributing to inflammatory lesions in the central nervous system
Vector Laboratories IHC‑plus Polyclonal Rabbit anti‑Human PTHR / PTHR1 Antibody Internal IHC LS‑A762
IHC‑plus Polyclonal Rabbit anti‑Human PTHR / PTHR1 Antibody Internal IHC LS‑A762
